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Metal 3D Printer Manufacturer Now Scaling New 3D Printed Nasal Swab

Markforged, a manufacturer of metal and carbon fiber 3D printers, is partnering with Neurophotometrics to produce Fiberflex Rayon, a 3D printed nasopharyngeal (NP) swab for use in diagnostic testing for COVID-19.

The new 3D printed swabs take just minutes to make, and in testing, they successfully detected the virus in all of the patients, while the commercial swabs reported false negatives. The team is currently producing 10,000 swabs per day, with plans to scale to 100,000 per day.

"Identifying COVID-19 infected patients is the best way to slow down the spread of the disease, but we're seeing a lot of issues with wide-scale testing," said Greg Mark, CEO and Founder of Markforged. "There are massive shortages of nasal swabs and to make matters worse, hospitals are reporting false negatives with the current swabs on the market."

In a collaborative effort by the San Diego Covid Research Enterprise Network (SCREEN) Initiative -- a group of scientists, students, research institutions, and others in the San Diego area -- Neurophotometrics, Rady Children's Hospital-San Diego, the Scripps Research Institute, and the University of California San Diego designed and tested the 3D printed swabs with fifty volunteers.

Patients that were confirmed to be positive for COVID-19 were re-tested three to fourteen days later with both the commercial swab and the 3D printed swab. Testing with the commercial swab detected the virus in most, but not all of the patients, while all of the 3D printed swabs came back positive, suggesting the 3D printed swab may be more efficient at collecting viral particles and may reduce the rate of false negatives.

The 3D printed design couples a 3D printed nylon swab base with a wrapped rayon tip to gather the viral specimens. The nasopharyngeal swabs must be both flexible enough to enter the nasal cavity and strong enough to withstand significant mechanical force or torsion without breaking or shearing. The 3D printed swab has been evaluated in testing to ensure it meets the mechanical demands of clinical use and assessed to be comparable to the mechanical performance of commercial swabs.

"Neurophotometrics collaborated with Markforged and medical professionals to scale this 3D printed swab at a rapid pace," said Sage Aronson, CEO and Founder of Neurophotometrics. "Markforged 3D printing enabled us to test more than 50 prototypes in 36 hours. And in the last two weeks, we've turned an idea into a viable product that's going to save lives."

The 3D printed swabs completed clinical validation with the institutional review board (IRB) at Rady Children's and the University of California San Diego, and the hospital has now ordered 30,000 swabs from Neurophotometrics to test patients within their facility.

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